The main goal of MEPHITIS is to significantly advance our understanding of protein synthesis in Plasmodium and to contribute to the effort on drug discovery against malaria.

Drug discovery is a multidisciplinary effort that depends on a solid structural and functional understanding of the intended molecular targets. Despite the vast amount of evidence that points at the translation machinery as an excellent objective for drug development programs, our level of understanding of that synthetic pathway in Plasmodium is surprisingly low.

Thus, this consortium aims at exploring a new avenue in the design of drugs against malaria by putting together a major effort towards the characterization of gene translation in its causing agent. [more info]