Sunday, May 25, 2013
members area

Consortium

MEPHITIS Consortium involves a team of scientists from 5 different countries, including two Indian research laboratories and is organized in three groups covering the following areas of research:

  • · Evolution and Structural Biology
  • · Molecular Biology and Biochemistry
  • ·Drug design and Discovery

The partners will carry out transversal research that will cover these general areas.

The overall structure of the consortium is represented as following:
Structural Studies&Evolution
·Dr. Amit Sharma
(3) Crystallography of tRNA-related enzymes
·Dr. Elisabetta Pizzi
(8) Modular evolution of Plasmodium ARSs
·Dr. Manuel Santos
(5) Codon usage in Plasmodium genomes
·Dr. Lluis Ribas de Pouplana
(1) Evolution of tRNA recognition in Plasmodium
Molecular Biology&biochemistry
·Dr. Magali Frugier
(4) Transport and regulation of Plasmodium tRNA
·Dr. Habib Saman
(9) Translation initiation in the apicoplast
·Dr. Manuel Santos
(5) Genomic analysis of effect of ARS inhibitors
·Dr. Lluis Ribas de Pouplana
(1) Anticodon recognition and error in Plasmodium
·Dr. Ralph Stuart
(7) tRNA aminoacylation in the apicoplast
Chemistry&drug design
·Dr. Miriam Royo
(6) Combinatorial chemistry of ARS inhibitors
·Dr. Amit Sharma
(3) In silico design of ARS inhibitors
·Dr. Lluis Ribas de Pouplana
(1) Noble selection strategies for ARS inhibitors
·Dr. Ralph Stuart
(7) Inhibitors of aminoacylation in the apicoplast