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Objectives
1.
To study the
protein translation machinery
of
Plasmodium
a.
To investigate the dynamics of tRNA in
Plasmodium
b.
To characterize the tRNA recognition mechanisms in the parasite
c.
To study gene translation in the apicoplast and cytosol of
Plasmodium
2.
To investigate
the effects of known translation inhibitors in the malaria parasite
a.
To characterize the activities of a large set of known and new inhibitors
b.
To investigate their different effects upon the parasite by array techniques
c.
To test their relative toxicity in a vertebrate model
3.
To identify and characterize
novel drug targets
in
Plasmodium falciparum
a.
To obtain structural data for several
Plasmodium
aminoacyl-tRNA synthetases.
b.
To obtain structural data for other components of the translation machinery.
c.
To determine their evolutionary history and proximity to human orthologs
4.
To generate
new lead compounds and improve the methods to select
them
falciparum
a.
To develope a new method of screening based on a positive selection scheme
b.
To use our data to design novel potential inhibitory scaffolds
c.
To synthesize several compound libraries and test their anti-malarial activity
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Project Completed
Phase 1
Phase 2
Phase 3
Project Completed
