a. To investigate the dynamics of tRNA in Plasmodium
b. To characterize the tRNA recognition mechanisms in the parasite
c. To study gene translation in the apicoplast and cytosol of Plasmodium
a. To characterize the activities of a large set of known and new inhibitors
b. To investigate their different effects upon the parasite by array techniques
c. To test their relative toxicity in a vertebrate model
a. To obtain structural data for several Plasmodium aminoacyl-tRNA synthetases.
b. To obtain structural data for other components of the translation machinery.
c. To determine their evolutionary history and proximity to human orthologs