Description: Within this WP we will proceed to the characterization of the effect of known and predicted ARS inhibitors on the infection cycle of erythrocytes by Plasmodium falciparum. This data will be useful for further studies in the development of ARS antagonists as potential anti-malarial drugs.
Description: This WP will study the translation machineries of human pathogens and the development of novel methods of antibiotic selection.
The study of tRNA recognition in model organisms has provided a detailed understanding of the general features of this process. We want to extend this knowledge to disease-causing species and apply it to the discovery of new therapeutics.
Description: The aim is to develop an innovative method for the discovery of ARS inhibitors.
We propose the use of a line of human cells, whose growth is arrested by a toxic Plasmodium ARS, as a tool for the positive selection of specific and non-toxic ARS inhibitors.
